abstract：:The key information processing units within gene regulatory networks are enhancers. Enhancer activity is associated with the production of tissue-specific noncoding RNAs, yet the existence of such transcripts during cardiac development has not been established. Using an integrated genomic approach, we demonstrate that...

journal_title：Journal of molecular and cellular cardiology

authors： Ounzain S,Pezzuto I,Micheletti R,Burdet F,Sheta R,Nemir M,Gonzales C,Sarre A,Alexanian M,Blow MJ,May D,Johnson R,Dauvillier J,Pennacchio LA,Pedrazzini T

更新日期：2014-11-01 00:00:00

abstract：:Cardiac arrhythmias are one of the main causes of death worldwide. Several studies have shown that inflammation plays a key role in different cardiac diseases and Toll-like receptors (TLRs) seem to be involved in cardiac complications. In the present study, we investigated whether the activation of TLR4 induces cardia...

journal_title：Journal of molecular and cellular cardiology

authors： Monnerat-Cahli G,Alonso H,Gallego M,Alarcón ML,Bassani RA,Casis O,Medei E

更新日期：2014-11-01 00:00:00

abstract：:Pathologic cardiac hypertrophy can lead to heart failure, but the mechanisms involved are poorly understood. SERCA2 is critical for normal cardiac calcium handling and function and SERCA2 mRNA and protein levels are reduced by cardiac hypertrophy. We hypothesized that extracellular signal-regulated kinase (ERK) 1/2 ac...

journal_title：Journal of molecular and cellular cardiology

authors： Huang H,Joseph LC,Gurin MI,Thorp EB,Morrow JP

更新日期：2014-10-01 00:00:00

abstract：:In cardiomyocytes, Ca(2+) plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical functions is achieved by segregating Ca(2+) within subcellular microdomains: transcription is regulated by Ca(2+) re...

journal_title：Journal of molecular and cellular cardiology

authors： Ibarra C,Vicencio JM,Varas-Godoy M,Jaimovich E,Rothermel BA,Uhlén P,Hill JA,Lavandero S

更新日期：2014-10-01 00:00:00

abstract：:A decade ago, stem or progenitor cells held the promise of tissue regeneration in human myocardium, with the expectation that these therapies could rescue ischemic myocyte damage, enhance vascular density and rebuild injured myocardium. The accumulated evidence in 2014 indicates, however, that the therapeutic success ...

journal_title：Journal of molecular and cellular cardiology

authors： Pavo N,Charwat S,Nyolczas N,Jakab A,Murlasits Z,Bergler-Klein J,Nikfardjam M,Benedek I,Benedek T,Pavo IJ,Gersh BJ,Huber K,Maurer G,Gyöngyösi M

更新日期：2014-10-01 00:00:00

abstract：:Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However, whether TT per se or the overall sarcolemma is altered during HF process is still unknown. In this study, we directly examined sarcolemmal surface topography and physica...

journal_title：Journal of molecular and cellular cardiology

authors： Dague E,Genet G,Lachaize V,Guilbeau-Frugier C,Fauconnier J,Mias C,Payré B,Chopinet L,Alsteens D,Kasas S,Severac C,Thireau J,Heymes C,Honton B,Lacampagne A,Pathak A,Sénard JM,Galés C

更新日期：2014-09-01 00:00:00

abstract：:The biological function of FAM3A, the first member of family with sequence similarity 3 (FAM3) gene family, remains largely unknown. This study aimed to determine its role in the proliferation and migration of vascular smooth muscle cells (VSMCs). Immunohistochemical staining revealed that FAM3A protein is expressed i...

journal_title：Journal of molecular and cellular cardiology

authors： Jia S,Chen Z,Li J,Chi Y,Wang J,Li S,Luo Y,Geng B,Wang C,Cui Q,Guan Y,Yang J

更新日期：2014-09-01 00:00:00

abstract：:Oxidative stress can be generated at several sites within the mitochondria. Among these, monoamine oxidase (MAO) has been described as a prominent source. MAOs are mitochondrial flavoenzymes responsible for the oxidative deamination of catecholamines, serotonin and biogenic amines, and during this process they generat...

journal_title：Journal of molecular and cellular cardiology

authors： Kaludercic N,Mialet-Perez J,Paolocci N,Parini A,Di Lisa F

更新日期：2014-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one important source for ROS are mitochondria. Emission of ROS from mitochondria is the net result of ROS production at the electron transport chain (ETC) and their elimination by antioxidative enzymes. Both of these processes are hig...

journal_title：Journal of molecular and cellular cardiology

authors： Nickel A,Kohlhaas M,Maack C

更新日期：2014-08-01 00:00:00

abstract：:It is increasingly evident that redox-dependent modifications in cellular proteins and signaling pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. Indeed, these redox modifications may be intricately linked with the process of hypertrophy wherein there is not only a significant...

journal_title：Journal of molecular and cellular cardiology

authors： Sag CM,Santos CX,Shah AM

更新日期：2014-08-01 00:00:00

abstract：:Structural and morphological changes of the cardiovascular systems (cardiovascular remodeling) are a major clinical outcome of cardiovascular diseases. Many lines of evidences have implied that transfiguration of reduction/oxidation (redox) homeostasis due to excess production of reactive oxygen species (ROS) and/or R...

journal_title：Journal of molecular and cellular cardiology

authors： Nishida M,Toyama T,Akaike T

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) have great potential as a cell source for therapeutic applications such as regenerative medicine, disease modeling, drug screening, and toxicity testing. This potential is limited, however, by the immature state of the cardiomyocyte...

journal_title：Journal of molecular and cellular cardiology

authors： Yang X,Rodriguez M,Pabon L,Fischer KA,Reinecke H,Regnier M,Sniadecki NJ,Ruohola-Baker H,Murry CE

更新日期：2014-07-01 00:00:00

abstract：:Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. The benefits of heart rate reduction by ivabradine during MODS are currently being investigated in the MODIfY clinical trial. Ivabradine is a selective inhibitor of the pa...

journal_title：Journal of molecular and cellular cardiology

authors： Scheruebel S,Koyani CN,Hallström S,Lang P,Platzer D,Mächler H,Lohner K,Malle E,Zorn-Pauly K,Pelzmann B

更新日期：2014-07-01 00:00:00

abstract：:Mammalian cardiomyocytes withdraw from the cell cycle shortly after birth, although it remains unclear how cardiomyocyte cell cycles behave during development. Compared to conventional immunohistochemistry in static observation, time-lapse imaging can reveal comprehensive data in hard-to-understand biological phenomen...

journal_title：Journal of molecular and cellular cardiology

authors： Hashimoto H,Yuasa S,Tabata H,Tohyama S,Hayashiji N,Hattori F,Muraoka N,Egashira T,Okata S,Yae K,Seki T,Nishiyama T,Nakajima K,Sakaue-Sawano A,Miyawaki A,Fukuda K

更新日期：2014-07-01 00:00:00

abstract：:In general, in most organ systems, intracellular protein homeostasis is the sum of many factors, including chromosomal state, protein synthesis, post-translational processing and transport, folding, assembly and disassembly into macromolecular complexes, protein stability and clearance. In the heart, there has been a ...

journal_title：Journal of molecular and cellular cardiology

authors： Sandri M,Robbins J

更新日期：2014-06-01 00:00:00

abstract：:Cardiac fibrosis is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure and cardiac arrhythmias. However the specific cells and signaling pathways mediating this process are poorly understood. Lysine acetylation of nucleosomal histone tails is an important mechanism fo...

journal_title：Journal of molecular and cellular cardiology

authors： Schuetze KB,McKinsey TA,Long CS

更新日期：2014-05-01 00:00:00

abstract：:Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme...

journal_title：Journal of molecular and cellular cardiology

authors： Lau D,Szöcs K,Klinke A,Rudolph T,Rudolph V,Streichert T,Blankenberg S,Baldus S

更新日期：2014-04-01 00:00:00

abstract：:Myocardial infarction (MI) provokes regional inflammation which facilitates the healing, whereas excessive inflammation leads to adverse cardiac remodelling. Our aim was to determine the role of macrophage migration inhibitory factor (MIF) in inflammation and cardiac remodelling following MI. Wild type (WT) or global ...

journal_title：Journal of molecular and cellular cardiology

authors： White DA,Su Y,Kanellakis P,Kiriazis H,Morand EF,Bucala R,Dart AM,Gao XM,Du XJ

更新日期：2014-04-01 00:00:00

abstract：:The ability of human pluripotent stem cells (hPSCs) to differentiate into any cell type of the three germ layers makes them a very promising cell source for multiple purposes, including regenerative medicine, drug discovery, and as a model to study disease mechanisms and progression. One of the first specialized cell ...

journal_title：Journal of molecular and cellular cardiology

authors： van den Heuvel NH,van Veen TA,Lim B,Jonsson MK

更新日期：2014-02-01 00:00:00

abstract：:Fibrosis, which is defined as excessive accumulation of fibrous connective tissue, contributes to the pathogenesis of numerous diseases involving diverse organ systems. Cardiac fibrosis predisposes individuals to myocardial ischemia, arrhythmias and sudden death, and is commonly associated with diastolic dysfunction. ...

journal_title：Journal of molecular and cellular cardiology

authors： Williams SM,Golden-Mason L,Ferguson BS,Schuetze KB,Cavasin MA,Demos-Davies K,Yeager ME,Stenmark KR,McKinsey TA

更新日期：2014-02-01 00:00:00

abstract：:Ca(2+) flux through l-type CaV1.2 channels shapes the waveform of the ventricular action potential (AP) and is essential for excitation-contraction (EC) coupling. Timothy syndrome (TS) is a disease caused by a gain-of-function mutation in the CaV1.2 channel (CaV1.2-TS) that decreases inactivation of the channel, which...

journal_title：Journal of molecular and cellular cardiology

authors： Drum BM,Dixon RE,Yuan C,Cheng EP,Santana LF

更新日期：2014-01-01 00:00:00

abstract：:Despite advances in the treatment of acute tissue ischemia significant challenges remain in effective cytoprotection from ischemic cell death. It has been documented that injected stem cells, such as mesenchymal stem cells (MSCs), can confer protection to ischemic tissue through the release of paracrine factors. The s...

journal_title：Journal of molecular and cellular cardiology

authors： Huang J,Guo J,Beigi F,Hodgkinson CP,Facundo HT,Zhang Z,Espinoza-Derout J,Zhou X,Pratt RE,Mirotsou M,Dzau VJ

更新日期：2014-01-01 00:00:00

abstract：:Atrial tachyarrhythmias, the most common type of cardiac arrhythmias, are associated with greater stroke risk. Muscarinic cholinergic agonists have been shown to facilitate atrial tachyarrhythmia maintenance in the absence of cardiac disease. This has been attributed to action potential shortening, which enhances myoc...

journal_title：Journal of molecular and cellular cardiology

authors： Zafalon N Jr,Oshiyama NF,Bassani JW,Bassani RA

更新日期：2013-12-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is associated with refractory vasoconstriction and impaired NO-mediated vasodilatation of the pulmonary vasculature. Vascular tone is regulated by light chain (LC) phosphorylation of both nonmuscle (NM) and smooth muscle (SM) myosins, which are determined by the activities of MLC ...

journal_title：Journal of molecular and cellular cardiology

authors： Konik EA,Han YS,Brozovich FV

更新日期：2013-12-01 00:00:00

abstract：:Cardiomyocytes represent one of the most useful models to conduct cardiac research. A single adult heart yields millions of cardiomyocytes, but these cells do not survive for long after isolation. We aimed to determine whether inhibition of myosin II ATPase that is essential for muscle contraction may preserve fully d...

journal_title：Journal of molecular and cellular cardiology

authors： Abi-Gerges N,Pointon A,Pullen GF,Morton MJ,Oldman KL,Armstrong D,Valentin JP,Pollard CE

更新日期：2013-11-01 00:00:00

abstract：:Cardiac myosin binding protein C (cMyBP-C) phosphorylation is differentially regulated in the normal heart and during disease development. Our objective was to examine in detail three phosphorylatable sites (Ser-273, Ser-282, and Ser-302) present in the protein's cardiac-specific sequences, as these residues are diffe...

journal_title：Journal of molecular and cellular cardiology

authors： Gupta MK,Gulick J,James J,Osinska H,Lorenz JN,Robbins J

更新日期：2013-11-01 00:00:00

abstract：:It has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts the equilibrium toward...

journal_title：Journal of molecular and cellular cardiology

authors： Inoue T,Kobirumaki-Shimozawa F,Kagemoto T,Fujii T,Terui T,Kusakari Y,Hongo K,Morimoto S,Ohtsuki I,Hashimoto K,Fukuda N

更新日期：2013-10-01 00:00:00

abstract：:Protein kinase C epsilon (PKCε) activation controls fibroblast growth factor-2 (FGF-2) angiogenic signaling. Here, we examined the effect of activating PKCε on FGF-2 dependent vascular growth and endothelial activation. ψεRACK, a selective PKCε agonist induces pro-angiogenic responses in endothelial cells, including f...

journal_title：Journal of molecular and cellular cardiology

authors： Monti M,Donnini S,Morbidelli L,Giachetti A,Mochly-Rosen D,Mignatti P,Ziche M

更新日期：2013-10-01 00:00:00

abstract：:To determine whether high free fatty acids (FFA) could affect the anti-contractile properties of perivascular adipose tissue (PVAT) in rat aortas. Wistar rats were divided into normal, obesity and fenofibrate groups and fed a normal, high-fat, and high-fat plus fenofibrate diet, respectively. Thoracic aortas with or w...

journal_title：Journal of molecular and cellular cardiology

authors： Sun X,Hou N,Han F,Guo Y,Hui Z,Du G,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:We have demonstrated that scar formation after myocardial infarction (MI) is associated with an endogenous pool of CD44(pos)CD45(neg) multipotential mesenchymal stem cells (MSC). MSC differentiate into fibroblasts secreting collagen that forms a scar and mature into myofibroblasts that express alpha smooth muscle acti...

journal_title：Journal of molecular and cellular cardiology

authors： Cieslik KA,Taffet GE,Crawford JR,Trial J,Mejia Osuna P,Entman ML

更新日期：2013-10-01 00:00:00

abstract：:The possibility to induce pluripotency in somatic cells or, even further, to induce cell transdifferentiation through the forced expression of reprogramming factors has offered new, attractive options for cardiovascular regenerative medicine. In fact, recent discoveries have demonstrated that induced pluripotent stem ...

journal_title：Journal of molecular and cellular cardiology

authors： Iglesias-García O,Pelacho B,Prósper F

更新日期：2013-09-01 00:00:00

abstract：:Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether hypercholesterolemia-induced myocardial microRNA alterations play a role in the development of oxidative...

journal_title：Journal of molecular and cellular cardiology

authors： Varga ZV,Kupai K,Szűcs G,Gáspár R,Pálóczi J,Faragó N,Zvara A,Puskás LG,Rázga Z,Tiszlavicz L,Bencsik P,Görbe A,Csonka C,Ferdinandy P,Csont T

更新日期：2013-09-01 00:00:00

abstract：:Cardiac hypertrophy has been well-characterized at the level of transcription. During cardiac hypertrophy, genes normally expressed primarily during fetal heart development are re-expressed, and this fetal gene program is believed to be a critical component of the hypertrophic process. Recently, alternative splicing o...

journal_title：Journal of molecular and cellular cardiology

authors： Ames EG,Lawson MJ,Mackey AJ,Holmes JW

更新日期：2013-09-01 00:00:00

abstract：:In this article we review the late Na current which functionally can be measured using patch-clamp electrophysiology (INa,late). This current is largely enhanced under pathological myocardial conditions such as ischemia and heart failure. In addition, INa,late can cause systolic and diastolic contractile dysfunction v...

journal_title：Journal of molecular and cellular cardiology

authors： Maier LS,Sossalla S

更新日期：2013-08-01 00:00:00

abstract：:Postacidotic arrhythmias have been associated to increased sarcoplasmic reticulum (SR) Ca(2+) load and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activation. However, the molecular mechanisms underlying these arrhythmias are still unclear. To better understand this process, acidosis produced by CO2 increas...

journal_title：Journal of molecular and cellular cardiology

authors： Lascano EC,Said M,Vittone L,Mattiazzi A,Mundiña-Weilenmann C,Negroni JA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The ability to recapitulate mature adult phenotypes is critical to the development of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) as models of disease. The present study examines the characteristics of the transient outward current (Ito) and its contribution to the hiPSC-CM action p...

journal_title：Journal of molecular and cellular cardiology

authors： Cordeiro JM,Nesterenko VV,Sicouri S,Goodrow RJ Jr,Treat JA,Desai M,Wu Y,Doss MX,Antzelevitch C,Di Diego JM

更新日期：2013-07-01 00:00:00

abstract：:Although protection against necrosis has been observed in both hibernating (HIB) and ischemic preconditioned hearts in the second window of protection (SWOP), a comparison of the mitochondrial proteome between the two entities has not been previously performed. Anesthetized swine underwent instrumentation with a fixed...

journal_title：Journal of molecular and cellular cardiology

authors： Cabrera JA,Butterick TA,Long EK,Ziemba EA,Anderson LB,Duffy CM,Sluiter W,Duncker DJ,Zhang J,Chen Y,Ward HB,Kelly RF,McFalls EO

更新日期：2013-07-01 00:00:00

abstract：:Somatic mutations and dysregulation by microRNAs (miRNAs) may have a pivotal role in the Congenital Heart Defects (CHDs). The purpose of the study was to assess both somatic and germline mutations in the GATA4 and NKX2.5 genes as well as to identify 3'UTR single nucleotide polymorphisms (SNPs) in the miRNA target site...

journal_title：Journal of molecular and cellular cardiology

authors： Sabina S,Pulignani S,Rizzo M,Cresci M,Vecoli C,Foffa I,Ait-Ali L,Pitto L,Andreassi MG

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Statins have been shown to increase the level of circulating progenitor cells in peripheral blood supposedly due to a mobilization of progenitor cells from the bone marrow niche. Osteoclast/osteoblast interaction has been associated with progenitor cell mobilization. Here, we investigated the role of statins...

journal_title：Journal of molecular and cellular cardiology

authors： Steinmetz M,Pelster B,Lucanus E,Arnal JF,Nickenig G,Werner N

更新日期：2013-04-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a disease characterized by dilation of the ventricular chambers and reduced contractile function. We examined the contractile performance of chemically-skinned ventricular strips from two heterozygous murine models of DCM-causing missense mutations of myosin, F764L/+ and S532P/+, in an ...

journal_title：Journal of molecular and cellular cardiology

authors： Palmer BM,Schmitt JP,Seidman CE,Seidman JG,Wang Y,Bell SP,Lewinter MM,Maughan DW

更新日期：2013-04-01 00:00:00